Investigating genetic factors that affect transplant outcomes.
Official title: MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN Studies
Funded at New York University School of Medicine · NIH-10875553 · Data updated 2026-11-12
This study is looking at how certain genes might help doctors match organ donors and recipients better, which could lead to more successful transplants for people needing kidneys, hearts, or lungs, and it includes a variety of patients to make sure the results are helpful for everyone.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $639,512 |
| NIH project number | 5U01AI152960-06 |
| Project ID | NIH-10875553 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are undergoing or have undergone organ transplantation, particularly those from diverse genetic backgrounds.
✕Less likely to help
Patients who are not candidates for organ transplantation or those with no genetic variations relevant to MHC and KIR may not benefit from this research.
What this research studies
This research focuses on understanding how specific genetic variations in the MHC and KIR regions influence the success of organ transplants, such as kidney, heart, and lung transplants. By analyzing a large database of over 52,600 transplant recipients and donors, the study aims to identify genetic markers that can improve donor-recipient matching. This could lead to better transplant outcomes and reduced rejection rates. The research also emphasizes the inclusion of diverse populations to ensure that findings are applicable to a wider range of patients.
Why it matters
Potential benefit: If successful, this research could lead to improved matching processes for organ transplants, enhancing patient outcomes and reducing the risk of transplant rejection.
How similar studies have gone: Previous studies have shown that genetic matching can significantly improve transplant outcomes, indicating that this approach has potential for success.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Keating, Brendan James — New York University School of Medicine
- Study coordinator: Keating, Brendan James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.