Investigating genetic factors that affect the immune system and insulin-producing cells in Type 1 diabetes.
Enhancer-based Immune and Beta Cell Dysregulation Underlying T1D Risk
This study is looking at how certain genes might affect the immune system and insulin-producing cells in people who are at risk for Type 1 diabetes, and it involves comparing samples from those with the condition and healthy individuals to better understand what causes the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10671012 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genetic variations influence the immune response and the function of insulin-producing beta cells in individuals at risk for Type 1 diabetes (T1D). By analyzing genomic data and using advanced techniques like CRISPR, the researchers aim to identify key genetic enhancers that contribute to T1D susceptibility. The study involves collecting samples from both T1D patients and healthy controls to compare immune and beta cell functions, ultimately seeking to uncover the underlying mechanisms of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Type 1 diabetes, particularly those with a family history of the disease.
Not a fit: Patients who are already diagnosed with Type 1 diabetes and are not at risk for genetic predisposition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Type 1 diabetes by targeting the genetic factors involved.
How similar studies have performed: Previous research has shown promise in using genomic editing techniques to understand autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Suh, Yousin — Columbia University Health Sciences
- Study coordinator: Suh, Yousin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.