Investigating genetic factors related to white matter changes in Alzheimer's disease
Genetic and molecular correlates of white matter pathology in Alzheimers disease
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11004952
This study is looking at how certain genes and cells in the brain might affect the loss of important white matter in people with Alzheimer's disease, and it invites patients to share their genetic information to help us learn more about this connection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11004952 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how genetic and molecular factors contribute to the loss of white matter in Alzheimer's disease (AD). It examines the role of oligodendrocytes, which are crucial for maintaining myelin and supporting neurons, and how their dysfunction may relate to cognitive decline in AD patients. By analyzing genetic variants and their impact on myelin abnormalities, the study aims to uncover new insights into the mechanisms of AD. Patients may be involved in providing genetic samples and clinical data to help identify these correlations.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new genetic insights that improve understanding and treatment of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of myelin and oligodendrocytes in neurodegenerative diseases, suggesting this approach could yield valuable insights.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOFLER, JULIA K — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: KOFLER, JULIA K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia