Investigating genetic factors related to cocaine addiction in rats
Official title: Systems genetics of premorbid and cocaine use traits in a rat reduced complexity cross
Funded at Northeastern University · NIH-10795945 · Data updated 2026-11-12
This study is looking at how genes might play a role in cocaine addiction and behaviors like impulsivity in rats, which could help us understand addiction better and find new ways to treat it.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 7, 2024 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $604,029 |
| NIH project number | 5U01DA055299-04 |
| Project ID | NIH-10795945 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would be individuals with a family history of cocaine addiction or those exhibiting traits of impulsivity and compulsivity.
✕Less likely to help
Patients who do not have a history of substance use disorders or related behavioral traits may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors that contribute to cocaine addiction and related behaviors in rats. By using a reduced complexity cross of spontaneously hypertensive rats, the study aims to identify genetic variations linked to traits such as impulsivity and compulsivity, which are associated with addiction. The researchers will employ advanced genetic and functional genomic techniques to pinpoint causal genes and variants that influence these behaviors. This approach could provide insights into the biological mechanisms underlying addiction and help in developing targeted treatments.
Why it matters
Potential benefit: If successful, this research could lead to new genetic insights that inform better prevention and treatment strategies for cocaine addiction in humans.
How similar studies have gone: Other research has shown success in identifying genetic factors related to addiction using similar rodent models, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Northeastern University
Boston, United States Active
Researchers
- Principal investigator: Bryant, Camron D — Northeastern University
- Study coordinator: Bryant, Camron D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.