Investigating genetic factors of coronary artery disease in people of African ancestry
Genome-wide association study of coronary artery disease in individuals of African ancestry
This study is looking at how our genes might affect the risk of coronary artery disease, especially in people of African ancestry, and it invites patients to share their genetic samples and health info to help find ways to improve prevention and treatment for this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10898079 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic basis of coronary artery disease (CAD), which is particularly prevalent among individuals of African ancestry. By utilizing large-scale genetic data from various established cohorts, the study aims to identify specific genetic loci associated with CAD and related traits. Patients will be involved in providing genetic samples and health information, which will help researchers uncover how genetic variations influence CAD risk and its mechanisms. The findings could lead to better-targeted prevention and treatment strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals of African ancestry who are at risk for or have been diagnosed with coronary artery disease.
Not a fit: Patients who do not have African ancestry or those without a history of coronary artery disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of coronary artery disease specifically for individuals of African ancestry.
How similar studies have performed: Previous genome-wide association studies have successfully identified genetic factors for coronary artery disease in other populations, but this approach is novel for African-ancestry populations.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Lu, Yingchang — Vanderbilt University Medical Center
- Study coordinator: Lu, Yingchang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.