Investigating genetic factors linking sleep loss and Alzheimer's disease
Systems Genetics Analysis of Alzheimer's Disease-Related Sleep Loss and the Transition to Dementia
This study is looking into how certain genes might affect sleep problems in people with Alzheimer's disease, using mice to help understand the connection and hoping to find ways to improve sleep and thinking for those living with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11030806 on NIH RePORTER |
What this research studies
This research aims to uncover genetic factors that contribute to sleep disturbances in individuals with Alzheimer's disease (AD). By using advanced mouse models, the study will explore how these genetic factors influence both sleep and cognitive symptoms associated with AD. The findings will be validated against human data to ensure relevance and applicability. Ultimately, the goal is to identify potential interventions that could improve sleep and cognitive function in patients with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing sleep disturbances related to Alzheimer's disease or those at risk for developing Alzheimer's.
Not a fit: Patients without sleep issues or those not affected by Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve sleep and cognitive health in individuals with Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Kaczorowski, Catherine Cook — University of Michigan at Ann Arbor
- Study coordinator: Kaczorowski, Catherine Cook
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.