Investigating genetic factors linked to type 2 diabetes
Official title: Stimulatory state specific genetic regulatory signatures at diabetes GWAS signals
Funded at University of Michigan at Ann Arbor · NIH-11083006 · Data updated 2026-11-12
This study is looking at how our genes might affect the risk of developing type 2 diabetes by examining how they interact with certain cells in our body, and it hopes to find new ways to help people manage or prevent diabetes based on their unique genetic makeup.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $41,753 |
| NIH project number | 5F31DK135342-03 |
| Project ID | NIH-11083006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of type 2 diabetes or those showing early signs of insulin resistance.
✕Less likely to help
Patients who do not have any genetic predisposition to type 2 diabetes or those with other unrelated metabolic disorders may not benefit from this research.
What this research studies
This research focuses on understanding the genetic signals associated with type 2 diabetes (T2D) by analyzing how these signals interact with specific cell types, particularly mesenchymal stem cells. The study employs advanced techniques to examine chromatin structure and gene expression, aiming to identify regulatory mechanisms that contribute to T2D risk. By exploring the role of proteins like follistatin, which influences muscle growth and insulin resistance, the research seeks to uncover how genetic predispositions can lead to diabetes development. Patients may benefit from insights that could lead to targeted therapies or preventive strategies based on their genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies for individuals at risk of developing type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in identifying genetic factors linked to diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Ventresca, Christa Nicole — University of Michigan at Ann Arbor
- Study coordinator: Ventresca, Christa Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.