Investigating genetic factors linked to multi-substance use in veterans
Genetic Vulnerability for Sustained Multi-Substance Use in MVP
This study is looking at how our genes might make some people more likely to use alcohol, tobacco, and prescription opioids together, especially in the African American community, to help us better understand the reasons behind these habits.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Philadelphia VA Medical Center NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10946719 on NIH RePORTER |
What this research studies
This research explores the genetic vulnerabilities associated with the combined use of alcohol, tobacco, and prescription opioids, particularly focusing on the African American population. By analyzing extensive clinical data from the Veterans Healthcare Administration and the Million Veteran Program, the study aims to identify shared genetic pathways that contribute to substance use behaviors. The research addresses challenges such as phenotypic ambiguity and measurement bias, which can affect the accuracy of clinical assessments. Ultimately, the goal is to enhance understanding of the genetic and environmental factors that influence substance use patterns.
Who could benefit from this research
Good fit: Ideal candidates for this research include African American veterans who have a history of substance use or are at risk for developing substance use disorders.
Not a fit: Patients who do not identify as African American or who do not have a history of substance use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for individuals at risk of multi-substance use.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to substance use, but this approach aims to address gaps in understanding shared genetic pathways, making it a novel endeavor.
Where this research is happening
Philadelphia, United States
- Philadelphia VA Medical Center — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kranzler, Henry Richard — Philadelphia VA Medical Center
- Study coordinator: Kranzler, Henry Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.