Investigating genetic factors linked to male-biased autism
Official title: Defining critical MECP2 cis-regulatory elements towards identifying genetic candidates for male-biased autism
Funded at Baylor College of Medicine · NIH-10996466 · Data updated 2026-11-12
This study is looking at how certain changes in a gene called MECP2 might play a role in autism, especially in boys, by exploring how these changes affect brain development and behavior, using cutting-edge tools to better understand the biology behind autism and find new genetic clues for future research.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32HD116501-01 |
| Project ID | NIH-10996466 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are young males aged 0-11 years who are diagnosed with autism spectrum disorder (ASD).
✕Less likely to help
Patients who are female or older than 11 years may not receive direct benefits from this research.
What this research studies
This research focuses on understanding how specific genetic elements related to the MECP2 gene may contribute to autism, particularly in males. By examining non-coding mutations in the MECP2 gene's regulatory regions, the study aims to identify how these mutations affect brain development and behavior. Researchers will use advanced techniques, including CRISPR, to manipulate these genetic elements in human neurons and assess their impact on MECP2 expression and related molecular characteristics. This could provide insights into the biological mechanisms underlying autism and help identify potential genetic candidates for further study.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions for autism in males.
How similar studies have gone: Previous research has shown promising results in understanding the role of MECP2 in neurodevelopmental disorders, indicating that this approach has potential for success.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Schuman, Rebecca Meyer — Baylor College of Medicine
- Study coordinator: Schuman, Rebecca Meyer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.