Investigating genetic factors linked to female infertility and egg chromosome issues.
Functional evaluation of kinesin gene variants associated with female subfertility and egg aneuploidy.
This study is looking at how certain genes in women might affect their chances of having healthy eggs and embryos, which is important for those facing infertility, and it hopes to find ways to predict the risk of chromosome issues in their pregnancies.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project ID | NIH-10897882 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genetic variations in women may contribute to infertility, particularly through the lens of egg and embryo aneuploidy, which is an abnormal number of chromosomes. By analyzing genetic data from women with varying rates of aneuploidy, the study aims to identify which kinesin gene variants are associated with a higher risk of this condition. The researchers will use mouse models to test the impact of these genetic variants on egg development and chromosome segregation. This approach could lead to the development of genetic tests that help predict a woman's risk of aneuploid conception.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of reproductive age who have experienced infertility or have had multiple miscarriages.
Not a fit: Patients who are not experiencing infertility or who have no history of aneuploidy-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new genetic tests that help women understand their risk of infertility due to aneuploidy, potentially guiding treatment options.
How similar studies have performed: While the specific approach of investigating kinesin gene variants is novel, previous research has shown that genetic factors can influence aneuploidy rates, indicating potential for success.
Where this research is happening
Piscataway, United States
- Rutgers, the State Univ of N.j. — Piscataway, United States (Active)
Researchers
- Principal investigator: Biswas, Leelabati — Rutgers, the State Univ of N.j.
- Study coordinator: Biswas, Leelabati
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.