Investigating genetic factors linked to autism spectrum disorder
Functional convergence following disruption of diverse genes associated with neurodevelopmental disorders
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11031974
This study is looking at how certain genetic changes might affect brain cell development in people with autism, using special techniques to see how these changes influence how brain cells work, with the hope of finding ways to better understand autism.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11031974 on ClinicalTrials.gov |
What this research studies
This research explores how various genetic mutations contribute to autism spectrum disorder (ASD) by examining their effects on brain cell development. Using advanced techniques like CRISPR, the team will create specific genetic changes in human stem cells to observe how these changes impact neuron function. The goal is to identify common pathways that lead to functional deficits in individuals with ASD, which could help in understanding the underlying mechanisms of the disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a diagnosis of autism spectrum disorder or those with a family history of ASD.
Not a fit: Patients without any genetic predisposition to autism spectrum disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic causes of autism, potentially informing future treatments and interventions.
How similar studies have performed: Other research has shown promising results in understanding genetic contributions to autism, making this approach both relevant and potentially impactful.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRENNAND, KRISTEN JENNIFER — YALE UNIVERSITY
- Study coordinator: BRENNAND, KRISTEN JENNIFER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder