Investigating genetic factors influencing Langerhans Cell Histiocytosis risk
Molecular Epidemiology of Langerhans Cell Histiocytosis: Evaluating the Impact of SMAD6 and Genetic Ancestry on Disease Risk
This study is looking into Langerhans Cell Histiocytosis (LCH) in kids to find out if certain genetic factors, like the SMAD6 variant, make some people more likely to get this condition, which could help improve how we diagnose and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10688298 on NIH RePORTER |
What this research studies
This research focuses on understanding Langerhans Cell Histiocytosis (LCH), a rare inflammatory condition that primarily affects children. The study aims to identify genetic factors, particularly the SMAD6 variant, that may increase the risk of developing LCH. By analyzing genetic ancestry and mutations, researchers hope to uncover why certain populations are more affected than others. This could lead to better diagnostic tools and targeted therapies for patients with LCH.
Who could benefit from this research
Good fit: Ideal candidates for this research include children diagnosed with Langerhans Cell Histiocytosis, particularly those from Hispanic backgrounds.
Not a fit: Patients with LCH who do not carry the identified genetic variants or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and personalized treatment options for patients with LCH.
How similar studies have performed: Previous research has successfully identified genetic mutations associated with other cancers, suggesting that this approach may yield valuable insights for LCH as well.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Scheurer, Michael E. — Baylor College of Medicine
- Study coordinator: Scheurer, Michael E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.