Investigating genetic factors in rapid kidney decline for diabetes patients
Genetic and Functional Analysis of Rapid Renal Decline in Diabetes: A Family-based Approach to Accelerate Gene Discovery
This study is looking at how genetics might play a role in the quick decline of kidney function in people with diabetes, and it's designed for those who want to understand more about their condition and potential new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11092227 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic basis of rapid renal decline in patients with diabetes, specifically through a family-based approach. By utilizing extensive databases that include medical records and genealogical data, the study aims to identify genetic variants that contribute to diabetic nephropathy. The researchers have already established a large cohort of diabetic patients with rapid kidney decline and have begun to uncover potential disease-causing genes. This innovative methodology could lead to significant advancements in personalized treatment options for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are experiencing rapid renal decline, particularly those with a family history of diabetic nephropathy.
Not a fit: Patients without diabetes or those whose renal decline is not linked to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved genetic understanding and targeted therapies for patients experiencing rapid kidney decline due to diabetes.
How similar studies have performed: Previous research has shown promise in using family-based approaches to uncover genetic factors in complex diseases, suggesting that this methodology could yield valuable insights.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Pezzolesi, Marcus Guy — University of Utah
- Study coordinator: Pezzolesi, Marcus Guy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.