Investigating genetic factors in nonsyndromic orofacial clefts using advanced statistical methods
Official title: Analyzing nonsyndromic orofacial clefts GWAS data with case-parent trio design
Funded at Arizona State University-Tempe Campus · NIH-10994829 · Data updated 2026-11-12
This study is looking at the genetic reasons behind cleft lip and palate to help find better ways to diagnose and treat these conditions, so that families affected by orofacial clefts can have more personalized care in the future.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | January 6, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2022 |
| Award (this year) | $101,948 |
| NIH project number | 7R03DE030259-04 |
| Project ID | NIH-10994829 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with nonsyndromic orofacial clefts and their parents.
✕Less likely to help
Patients without orofacial clefts or those with syndromic forms of clefts may not benefit from this research.
What this research studies
This research focuses on understanding the genetic causes of nonsyndromic orofacial clefts, such as cleft lip and palate, by analyzing data from case-parent trio designs. The study aims to improve the detection of genetic variants associated with these conditions using innovative statistical methods that enhance the power of existing tests. By identifying new genetic risk factors, the research seeks to provide insights into the mechanisms behind these birth defects, which could lead to improved diagnostics and therapies. Patients with orofacial clefts may benefit from the findings as they could inform more targeted treatment options in the future.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with nonsyndromic orofacial clefts.
How similar studies have gone: Previous studies using advanced statistical methods in genetic research have shown promise, indicating potential for success in this approach.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Chen, Zhongxue — Arizona State University-Tempe Campus
- Study coordinator: Chen, Zhongxue
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.