Investigating genetic factors in neuroimmune disorders linked to cancer
KIR and HLA effects in CNS paraneoplastic syndromes and related neuroimmune conditions
This study is looking at how certain genes might affect neuroimmune disorders linked to cancer, and it's for patients who have these conditions; by examining blood samples from around 2000 people, researchers hope to find clues that could lead to better treatments and improved health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11099932 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors, specifically KIR and HLA genes, that may influence neuroimmune disorders associated with paraneoplastic syndromes. By analyzing blood samples and genetic data from patients, the study aims to identify specific autoantibodies and their relationship to symptoms. The research will involve collecting serum and DNA from approximately 2000 patients, utilizing advanced sequencing techniques to gain insights into the genetic underpinnings of these conditions. This could help in developing targeted therapies and improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neuroimmune disorders, particularly those associated with paraneoplastic syndromes.
Not a fit: Patients without neuroimmune disorders or those not associated with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and personalized treatment options for patients with neuroimmune disorders.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors of similar neuroimmune conditions, indicating potential for success in this area.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Mignot, Emmanuel J — Stanford University
- Study coordinator: Mignot, Emmanuel J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.