Investigating genetic factors in neurodegenerative diseases
Genetic Analysis of Neurodegeneration
This study is looking at how certain genes affect brain diseases like Parkinson's and Alzheimer's as we age, using fruit flies to help find important clues that could lead to new treatments for people with these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11080984 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic mechanisms behind neurodegenerative diseases like Parkinson's and Alzheimer's, particularly as they relate to aging. Using fruit flies as a model organism, researchers aim to identify key genes involved in neurodegeneration and validate these findings in human tissues and cells. The study will specifically explore how alterations in the spectrin cytoskeleton contribute to neurodegeneration, which could lead to new therapeutic targets. By leveraging advanced genetic screening techniques, the research seeks to uncover novel insights into disease processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing symptoms of neurodegenerative diseases, particularly those related to aging.
Not a fit: Patients with neurodegenerative diseases not associated with age or those in very early stages of disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of disease-modifying therapies for neurodegenerative conditions.
How similar studies have performed: Previous research using similar genetic models has shown promise in identifying potential therapeutic targets for neurodegenerative diseases.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Feany, Mel B — Brigham and Women's Hospital
- Study coordinator: Feany, Mel B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.