Investigating genetic factors in neonatal seizures and their link to epilepsy
NSR-GENE (Neonatal Seizure Registry, GEnetics of post-Neonatal Epilepsy)
This study is looking at how genes might affect the chances of kids getting epilepsy after having seizures as newborns due to brain injury, and it aims to help doctors better predict which children might be at risk by using simple genetic tests along with other health checks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11016944 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic factors influence the risk of developing epilepsy in children who have experienced neonatal seizures due to brain injury. By utilizing a large cohort of children with acute symptomatic neonatal seizures, the study will conduct non-invasive genetic testing alongside clinical assessments, EEG, and MRI data. The goal is to identify specific genetic variants and pathways that may contribute to the development of epilepsy, thereby enhancing predictive models for at-risk children.
Who could benefit from this research
Good fit: Ideal candidates for participation are children who have experienced acute symptomatic neonatal seizures and their families.
Not a fit: Patients who have not experienced neonatal seizures or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted interventions for children at high risk of developing epilepsy after neonatal seizures.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to epilepsy, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Glass, Hannah Cranley — University of California, San Francisco
- Study coordinator: Glass, Hannah Cranley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.