Investigating genetic factors in multiple myeloma disparities
WHOLE EXOME SEQUENCING FOR NCI (COZEN)
This study is looking at how genes and the environment might explain why Black individuals are more likely to develop multiple myeloma, and it’s for people with related conditions like monoclonal gammopathy, to help us understand these differences better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10949127 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic and environmental factors that contribute to the higher incidence of multiple myeloma (MM) among Black individuals compared to other racial groups. By analyzing DNA samples from patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma, the study aims to identify genetic variations that may influence the risk of developing these conditions. The research will utilize whole exome sequencing to capture a comprehensive view of genetic differences and will compare findings with a control group of Black prostate cancer patients. This approach seeks to fill critical knowledge gaps regarding the disparities in MM risk across different racial and ethnic populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include Black individuals with a diagnosis of monoclonal gammopathy of undetermined significance (MGUS) or multiple myeloma.
Not a fit: Patients who do not identify as Black or do not have MGUS or multiple myeloma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and targeted prevention strategies for multiple myeloma, particularly in high-risk populations.
How similar studies have performed: Previous research has shown success in identifying genetic factors associated with cancer disparities, making this approach promising for uncovering new insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Doheny, Kimberly F — Johns Hopkins University
- Study coordinator: Doheny, Kimberly F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.