Investigating genetic factors in lung cancer among African Americans
Official title: CIDR: SEQUENCING SERVICES USING WHOLE GENOME SEQUENCING FOR NCI (AMOS),
Funded at Johns Hopkins University · NIH-10949101 · Data updated 2026-11-12
This study is looking at the genes that might make some African Americans more likely to get lung cancer, especially those with a family history of the disease, to help us find new ways to understand and assess their risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 11, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $861,840 |
| NIH project number | 268201700006I-0-759202300005-1 |
| Project ID | NIH-10949101 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American individuals with a family history of lung cancer.
✕Less likely to help
Patients without a family history of lung cancer or those from other racial/ethnic backgrounds may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors that contribute to lung cancer, particularly in African Americans who experience higher rates of incidence and mortality. By utilizing whole genome sequencing, the study aims to identify rare genetic variants that may increase the risk of familial lung cancer in this population. The approach includes analyzing data from high-risk families and comparing it with existing genomic data from African populations to uncover unique genetic markers. This comprehensive analysis seeks to enhance our understanding of lung cancer genetics and improve risk assessment.
Why it matters
Potential benefit: If successful, this research could lead to better identification of genetic risk factors for lung cancer in African Americans, potentially improving prevention and treatment strategies.
How similar studies have gone: While there have been successful studies on lung cancer genetics in other populations, this specific focus on African Americans and familial lung cancer is novel and has not been extensively explored.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Doheny, Kimberly F — Johns Hopkins University
- Study coordinator: Doheny, Kimberly F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.