Investigating genetic factors in liver cancer risk
Hereditary Genetics of Hepatocellular Carcinoma
This study is looking at how genetics might play a role in liver cancer, especially for people who have a family history of the disease, to help find out if certain inherited traits could increase the risk and guide better treatment options.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10888991 on NIH RePORTER |
What this research studies
This research focuses on understanding the hereditary genetics associated with hepatocellular carcinoma (HCC), a severe form of liver cancer. It aims to identify inherited genetic variants that may increase the risk of developing HCC, particularly in individuals with a family history of the disease. By analyzing genetic data from patients with HCC, the study seeks to uncover potential pathogenic gene variants that could inform treatment options. The research involves a detailed examination of personal and family cancer histories, risk factors, and genetic testing results to establish connections between inherited traits and cancer development.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of liver cancer or those diagnosed with hepatocellular carcinoma.
Not a fit: Patients without a family history of liver cancer or those with other unrelated cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted therapies for patients at higher risk of hepatocellular carcinoma.
How similar studies have performed: Previous research has shown promising results in identifying genetic factors linked to various cancers, suggesting that this approach may yield valuable insights for hepatocellular carcinoma as well.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Wangensteen, Kirk J — Mayo Clinic Rochester
- Study coordinator: Wangensteen, Kirk J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.