Investigating genetic factors in leukemia and treatment resistance
Core 1: Genomics
This study is looking at the genes and other factors that might cause acute myeloid leukemia (AML) and why some treatments don't work, so that we can find better ways to help patients by personalizing their therapies based on their unique genetic makeup.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10862889 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic, transcriptional, and epigenetic factors that contribute to the development of acute myeloid leukemia (AML) and its resistance to therapies. By analyzing a wide range of genomic data, the team aims to identify potential therapeutic targets and vulnerabilities that could improve treatment outcomes. Patients may benefit from advanced bioinformatics techniques that help tailor therapies based on individual genetic profiles. The research involves collaboration with various experts to ensure robust experimental design and data analysis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia who are seeking innovative treatment options.
Not a fit: Patients with other types of leukemia or those not diagnosed with leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with acute myeloid leukemia.
How similar studies have performed: Previous research has shown success in using genomic approaches to identify treatment targets in various cancers, indicating a promising avenue for this study.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Papaemmanuil, Elli — Sloan-Kettering Inst Can Research
- Study coordinator: Papaemmanuil, Elli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.