Investigating genetic factors in immunity to herpes simplex virus and its link to blindness
FCGRIIIA and IGHG (GM) Genotypes and Immunity to HSV1 in Herpes Stromal Keratitis
This study is looking at how certain genes might affect the immune system's response to the herpes virus, which can cause a serious eye condition that can lead to blindness, and it's for people who are at risk of developing this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10675575 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain genetic factors influence the immune response to herpes simplex virus type 1 (HSV1), which can lead to herpes stromal keratitis (HSK), a major cause of infectious blindness. The study will analyze specific genes related to immunoglobulin GM allotypes and their interaction with viral proteins to determine their role in the development of HSK. By examining DNA from patients with HSK, the researchers aim to identify genetic markers that could predict susceptibility to this condition. This could ultimately lead to better prevention and treatment strategies for those at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with herpes stromal keratitis or are HSV1-infected and at risk of developing this condition.
Not a fit: Patients who do not have HSV1 or have not experienced any related eye conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting and preventing blindness caused by herpes infections.
How similar studies have performed: While the specific genetic interactions being studied are novel, previous research has shown that genetic factors can influence immune responses to viral infections.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Pandey, Janardan P — Medical University of South Carolina
- Study coordinator: Pandey, Janardan P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.