Investigating genetic factors in idiopathic pulmonary fibrosis in older adults
Official title: Multi-omic profiling of IPF endotypes
Funded at Columbia University Health Sciences · NIH-11056803 · Data updated 2026-11-12
This study is looking at how genetics might affect the lung disease idiopathic pulmonary fibrosis (IPF) in older adults, hoping to find different genetic types that could help doctors create more personalized treatments for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $166,079 |
| NIH project number | 5K08HL169926-02 |
| Project ID | NIH-11056803 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who have been diagnosed with idiopathic pulmonary fibrosis.
✕Less likely to help
Patients under the age of 65 or those without a diagnosis of idiopathic pulmonary fibrosis may not benefit from this research.
What this research studies
This research focuses on understanding the genetic influences of idiopathic pulmonary fibrosis (IPF), a serious lung condition affecting older adults. The study aims to identify distinct genetic profiles, or endotypes, within IPF patients based on their telomere lengths and associated gene variants. By analyzing data from over 2,100 IPF cases and 12,000 controls, the research will explore how these genetic differences impact disease progression and patient outcomes. This approach could lead to more personalized treatment strategies for those affected by IPF.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with idiopathic pulmonary fibrosis.
How similar studies have gone: Previous research has shown promise in identifying genetic factors in other lung diseases, suggesting potential for success in this novel approach to IPF.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Zhang, Da — Columbia University Health Sciences
- Study coordinator: Zhang, Da
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.