Investigating genetic factors in heart muscle thickening
Official title: TOPMed WGS and Molecular Epidemiology Analyses for Cardiac Hypertrophy Phenotypes
Funded at Medical College of Wisconsin · NIH-10930193 · Data updated 2026-11-12
This study is looking at how certain genes might affect the thickening of the heart's left ventricle, which can lead to heart problems, and it's for anyone interested in understanding the genetic factors behind heart health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 23, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $807,948 |
| NIH project number | 1R56HL167896-01 |
| Project ID | NIH-10930193 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of cardiovascular diseases or those diagnosed with left ventricular hypertrophy.
✕Less likely to help
Patients without any cardiovascular conditions or genetic predispositions to heart disease may not benefit from this research.
What this research studies
This research focuses on understanding left ventricular hypertrophy (LVH), a condition where the heart's left ventricle thickens, increasing the risk of serious cardiovascular diseases. By analyzing genetic data from over 26,000 samples, the study aims to identify specific gene variants associated with LVH. Researchers will use human induced pluripotent stem cells (hiPSCs) to model these genetic factors and explore their functional implications. This approach allows for a deeper understanding of how genetics influence heart health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic causes of heart disease, potentially guiding personalized treatment strategies for patients.
How similar studies have gone: Previous research utilizing genetic analysis and human stem cell models has shown promise in understanding complex cardiovascular conditions, indicating a potential for success in this approach.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Broeckel, Ulrich — Medical College of Wisconsin
- Study coordinator: Broeckel, Ulrich
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.