Investigating genetic factors in heart failure with preserved ejection fraction
Genetic variation in xanthine oxidase and heart failure preserved ejection fraction
['FUNDING_OTHER'] · BIRMINGHAM VA MEDICAL CENTER · NIH-10951524
This study is looking at how certain genetic differences in a protein called xanthine oxidase might affect heart failure with preserved ejection fraction in people with high blood pressure, and it hopes to find new ways to help manage this condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BIRMINGHAM VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-10951524 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how genetic variations in xanthine oxidase (XOR) may contribute to heart failure with preserved ejection fraction (HFpEF), particularly in patients with hypertension. The study aims to explore the role of XOR in heart function and its potential as a new treatment target. By examining the relationship between XOR activity and heart muscle cell function, the research seeks to identify innovative therapeutic strategies for managing HFpEF. Patients may be involved in assessments that help clarify the genetic factors influencing their heart condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with hypertension and symptoms of heart failure, particularly those of African American descent.
Not a fit: Patients with heart failure due to reduced ejection fraction or those without hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from heart failure with preserved ejection fraction.
How similar studies have performed: Previous research has shown promising results in targeting xanthine oxidase for cardiovascular conditions, suggesting potential for success in this novel approach.
Where this research is happening
BIRMINGHAM, UNITED STATES
- BIRMINGHAM VA MEDICAL CENTER — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DELL'ITALIA, LOUIS J. — BIRMINGHAM VA MEDICAL CENTER
- Study coordinator: DELL'ITALIA, LOUIS J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.