Investigating genetic factors in autism using nonhuman primate models
Genetic Strategies for Neurodevelopmental Research
This study is looking at the genetic reasons behind Autism Spectrum Disorder by creating a special model using primates, which will help researchers learn more about how autism affects behavior and find better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11001439 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic causes of Autism Spectrum Disorder (ASD) by developing a nonhuman primate model that mimics the condition. Researchers will use advanced genetic techniques, specifically CRISPR/Cas9, to modify the CHD8 gene, which is frequently mutated in individuals with ASD. By studying these modified primates, the team aims to uncover the neurobiological mechanisms underlying autism and identify potential targets for effective treatments. This approach seeks to provide insights that traditional rodent models may not fully capture, particularly regarding cognitive and social behaviors.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with Autism Spectrum Disorder, particularly those with genetic mutations related to the CHD8 gene.
Not a fit: Patients without a diagnosis of Autism Spectrum Disorder or those whose condition is not linked to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for children with autism.
How similar studies have performed: Previous research using genetic modifications in animal models has shown promise, but this specific approach using nonhuman primates is relatively novel.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Amaral, David G — University of California at Davis
- Study coordinator: Amaral, David G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.