Investigating genetic factors in Alzheimer's disease using human and fruit fly models
Functional Genomic Dissection of Alzheimer's Disease in Humans and Drosophila Models
This study is looking at how certain genes might influence Alzheimer's disease by exploring how our bodies handle fats and stress at a cellular level, using both human cells and fruit flies, to find new ways to help people with Alzheimer's.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11124474 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors that contribute to Alzheimer's disease by examining specific biological pathways related to lipid metabolism and cellular stress responses. Researchers will use advanced techniques involving both human stem cell cultures and fruit fly models to explore how these pathways interact and affect the risk of developing Alzheimer's. By integrating findings from both model systems, the study aims to uncover mechanisms that could lead to new therapeutic strategies for Alzheimer's disease. Patients may benefit from insights gained into the genetic underpinnings of their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those who carry genetic risk factors such as the APOE ε4 allele.
Not a fit: Patients who do not have a genetic predisposition to Alzheimer's disease or who are not experiencing cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target the underlying genetic causes of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors in Alzheimer's disease, making this approach both relevant and potentially impactful.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Shulman, Joshua M — Baylor College of Medicine
- Study coordinator: Shulman, Joshua M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.