Investigating genetic factors in Alzheimer's Disease using brain cell types
Official title: Cell-type Specific Interrogation of Variant Function in Alzheimer's Disease
Funded at Univ of North Carolina Chapel Hill · NIH-10915454 · Data updated 2026-11-12
This study is looking at how certain genes might affect brain cells in people with Alzheimer's Disease, with the hope that understanding these genetic differences can help develop new treatments for the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | August 4, 2023 |
| Project end | August 3, 2026 |
| Funding year | 2024 |
| Award (this year) | $40,791 |
| NIH project number | 5F31AG084224-02 |
| Project ID | NIH-10915454 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of Alzheimer's Disease or those identified as at risk due to genetic factors.
✕Less likely to help
Patients with non-genetic forms of dementia or those without any familial or genetic predisposition to Alzheimer's Disease may not benefit from this research.
What this research studies
This research focuses on understanding the genetic variants that contribute to Alzheimer's Disease (AD) by examining how these variants affect the function of different brain cell types, including neurons, astrocytes, and microglia. By utilizing advanced genomic technologies and human induced pluripotent stem cells (hiPSCs), the study aims to identify which genetic variants influence the regulation of genes associated with AD. Patients may benefit from insights gained that could lead to new therapeutic strategies targeting the underlying genetic causes of the disease.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that address the genetic factors contributing to Alzheimer's Disease.
How similar studies have gone: Previous research utilizing similar genomic approaches has shown promise in identifying genetic factors in other diseases, suggesting potential success in this novel application for Alzheimer's Disease.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Bond, Marielle Louise — Univ of North Carolina Chapel Hill
- Study coordinator: Bond, Marielle Louise
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.