Investigating genetic factors in Alzheimer's disease using a new 3D brain model
Study of cell-type specific Alzheimer's disease genetic variants using a novel bioengineered model of iPSC-derived neural tissue
['FUNDING_R01'] · TUFTS UNIVERSITY BOSTON · NIH-10840301
This study is looking at how certain genes, especially the APOE gene, might affect Alzheimer's disease by using a special lab-created brain model, which helps researchers learn more about how different brain cells work together in the disease, with the hope of finding better treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10840301 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the genetic variants associated with Alzheimer's disease by utilizing a novel bioengineered model made from induced pluripotent stem cells (iPSCs). The approach involves creating a 3D neural tissue model that mimics the human brain environment, allowing researchers to study how different cell types, such as astrocytes and microglia, interact and contribute to the disease. By examining the effects of specific genetic variants, particularly those related to the APOE gene, the research aims to uncover new insights into the mechanisms of Alzheimer's disease. Patients may benefit from this research as it could lead to improved understanding and potential new treatments for Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those who carry the APOE ε4 allele.
Not a fit: Patients who do not have a genetic predisposition to Alzheimer's disease or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into the genetic factors influencing Alzheimer's disease, potentially leading to better prevention and treatment strategies.
How similar studies have performed: Other research has shown promise in using 3D models to study neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TESCO, GIUSEPPINA — TUFTS UNIVERSITY BOSTON
- Study coordinator: TESCO, GIUSEPPINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.