Investigating genetic factors in Alzheimer's disease among Latinos
Official title: GLASS-AD: Global Latinos Sequencing Study for Alzheimer's Disease
Funded at Columbia University Health Sciences · NIH-10935947 · Data updated 2026-11-12
This study is looking at the genes that might affect the risk of Alzheimer's disease in Hispanic and Latino people, and it's inviting individuals with Latino ancestry to help researchers find out more about both harmful and helpful genetic traits related to the condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $2,682,382 |
| NIH project number | 5U01AG081817-02 |
| Project ID | NIH-10935947 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include Hispanic or Latino individuals, particularly those with a family history of Alzheimer's disease or related conditions.
✕Less likely to help
Patients who do not identify as Hispanic or Latino or those without a family history of Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors that contribute to Alzheimer's disease in Hispanic and Latino populations, who are at a higher risk compared to non-Hispanic Whites. By conducting whole genome sequencing on a diverse group of 6,000 individuals with Latino ancestry, the study aims to identify both risky and protective genetic variants associated with Alzheimer's. The research will leverage existing cohorts and recruit new participants from Peru and Bolivia to ensure a comprehensive representation of genetic diversity. This approach will help in uncovering rare genetic variants that may influence Alzheimer's disease risk.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of Alzheimer's disease risk factors in Latino populations, potentially informing targeted prevention and treatment strategies.
How similar studies have gone: Previous research has shown success in identifying genetic variants related to Alzheimer's disease in diverse populations, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Tosto, Giuseppe — Columbia University Health Sciences
- Study coordinator: Tosto, Giuseppe
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.