Investigating genetic factors in Alzheimer's disease among diverse populations
Official title: Whole Genome Sequencing and Admixture Analyses of Neuropathologic Traits in Diverse Cohorts in USA and Brazil
Funded at Rush University Medical Center · NIH-10901834 · Data updated 2026-11-12
This study is looking at the genes and proteins that may contribute to Alzheimer's disease and similar conditions, especially in people of African ancestry, to help find better treatments for everyone affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $3,731,942 |
| NIH project number | 5R01AG075927-02 |
| Project ID | NIH-10901834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals of African ancestry who are experiencing symptoms of Alzheimer's disease or related dementias.
✕Less likely to help
Patients who do not have Alzheimer's disease or related dementias, or those not of African ancestry, may not benefit from this research.
What this research studies
This research aims to identify the genetic and protein-based drivers of Alzheimer's disease and related dementias, particularly focusing on individuals of African ancestry. By utilizing whole genome sequencing and analyzing diverse cohorts from the USA and Brazil, the study seeks to uncover the molecular traits associated with these conditions. Participants will include individuals from various backgrounds, and the research will leverage existing data from ongoing studies to enhance understanding of Alzheimer's pathology. The findings could lead to more targeted treatments and interventions for affected populations.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease and related dementias, particularly in diverse populations.
How similar studies have gone: Previous research has successfully identified molecular drivers of Alzheimer's disease in non-Latinx white populations, making this approach promising for diverse cohorts.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Bennett, David Alan — Rush University Medical Center
- Study coordinator: Bennett, David Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.