Investigating genetic factors in Alzheimer's disease among Caribbean Hispanics
Genetic Epidemiology and Multi-Omics Analyses in Familial and Sporadic Alzheimer's Disease Among Secular Caribbean Hispanics and Religious Order
This study is looking at how genes and other biological factors affect Alzheimer's disease in Caribbean Hispanics, and it invites participants to share samples like blood to help researchers learn more about the disease and how it might be different in various groups of people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10812465 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic and molecular factors contributing to both familial and sporadic Alzheimer's disease (AD) in Caribbean Hispanics. By integrating genetic analyses with advanced techniques like epigenomics, transcriptomics, proteomics, and metabolomics, the study aims to uncover how gene variants influence the disease and identify the proteins and pathways involved. Participants may provide biological samples, such as blood and cerebrospinal fluid, to help researchers gain insights into the disease's mechanisms and compare findings with other populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals of Caribbean Hispanic descent, particularly those with a family history of Alzheimer's disease or those diagnosed with sporadic AD.
Not a fit: Patients who do not identify as Caribbean Hispanic or those without a family history of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potentially new treatments for Alzheimer's disease in Caribbean Hispanic populations.
How similar studies have performed: Previous research has shown success in genetic studies of Alzheimer's disease, particularly in diverse populations, indicating that this approach has the potential for meaningful insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Mayeux, Richard P — Columbia University Health Sciences
- Study coordinator: Mayeux, Richard P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.