Investigating genetic factors in Alzheimer's disease
Official title: Studying roles of CASP8 SVA GGGAGA repeat expansions in Alzheimer's disease
Funded at University of Florida · NIH-11134911 · Data updated 2026-11-12
This study is looking at how a specific gene might affect Alzheimer's disease by examining brain samples from people with the condition, hoping to find clues that could help improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $507,371 |
| NIH project number | 1R01AG093746-01 |
| Project ID | NIH-11134911 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those with late-onset forms.
✕Less likely to help
Patients with early-onset Alzheimer's disease caused by known genetic mutations may not benefit from this research.
What this research studies
This research focuses on understanding the genetic contributions to Alzheimer's disease (AD), particularly the role of a specific genetic expansion in the CASP8 gene. Researchers will analyze brain samples from individuals with AD to identify the presence of polyGR+ aggregates and their association with cognitive decline. By employing advanced genetic techniques, the study aims to uncover how these genetic factors influence the development and progression of Alzheimer's disease. This could lead to new insights into potential treatment strategies for patients.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for Alzheimer's disease.
How similar studies have gone: Other research has shown promising results in exploring genetic factors in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Nguyen, Lien — University of Florida
- Study coordinator: Nguyen, Lien
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.