Investigating genetic factors in Alzheimer's disease
Additional Sequencing for the Alzheimer's Disease Sequencing Project (ADSP)
This study is looking at how different genes might affect the risk of developing Alzheimer's disease, especially in diverse communities, to help us understand the condition better and find ways to improve care for everyone.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10886051 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic variations that contribute to Alzheimer's disease (AD) by utilizing large-scale sequencing techniques. The project aims to identify both common and rare genetic variants that may increase the risk of developing AD or provide protection against it. By including diverse populations, particularly underserved racial and ethnic groups, the study seeks to uncover new insights into the genetic underpinnings of AD and address health disparities. Participants will undergo whole genome sequencing to generate comprehensive genetic data that can lead to better understanding and potential interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from diverse racial and ethnic backgrounds who are at risk for or diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients who do not have a genetic predisposition to Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved genetic understanding of Alzheimer's disease, potentially informing prevention and treatment strategies.
How similar studies have performed: Previous genetic studies in Alzheimer's disease have shown promise in identifying risk factors, suggesting that this approach could yield valuable insights as well.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Vance, Jeffery Marvin — University of Miami School of Medicine
- Study coordinator: Vance, Jeffery Marvin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.