Investigating genetic factors in ALS and FTD using whole genome sequencing data.
Comprehensive Harmonization and Analysis of Case/Control Whole Genome Sequencing Data from the ALS/FTD Compute Project
This study is looking at the genes behind ALS and Frontotemporal Dementia to find out what might cause these conditions, with the hope that understanding these genetic factors can lead to better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10592917 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic causes of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) by analyzing whole genome sequencing data. The project aims to harmonize and combine data from various major sequencing efforts across the United States to identify rare genetic variants and structural changes that may contribute to these neurodegenerative diseases. By leveraging large cohorts of data, the research seeks to uncover previously unexplained genetic factors that could lead to better understanding and treatment options for patients. Patients may benefit from advancements in genetic insights that could inform future therapies and interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with ALS or FTD, as well as their family members who may carry genetic risk factors.
Not a fit: Patients with other unrelated neurodegenerative disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic underpinnings of ALS and FTD, potentially improving diagnosis and treatment options for patients.
How similar studies have performed: Previous research has shown success in identifying genetic factors in ALS and FTD, but this project aims to expand on those findings with a novel approach using harmonized whole genome sequencing data.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Landers, John E — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Landers, John E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.