Investigating genetic factors in aggressive prostate cancer among African American men
The Clinical and Epidemiological Characterization of Pathogenic DNA Damage Repair Pathway Variation in Prostate Cancer
This study is looking at how certain genetic differences might affect the way prostate cancer develops, especially in African American men who are more likely to have aggressive forms of the disease, by examining blood samples to find markers that could help predict how serious the cancer might be.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10922775 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic variations in DNA damage repair pathways that may lead to aggressive forms of localized prostate cancer, particularly in African American men who are at higher risk. By analyzing blood samples from patients with high-risk prostate cancer, the study aims to identify specific genetic markers that could predict disease severity and outcomes. The approach includes both retrospective and prospective analysis of patient cohorts to establish a clearer link between genetic factors and cancer aggressiveness.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American men diagnosed with high-risk, localized prostate cancer.
Not a fit: Patients with low-risk prostate cancer or those outside the African American demographic may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for identifying patients at high risk for aggressive prostate cancer, allowing for more personalized treatment strategies.
How similar studies have performed: Previous research has shown promise in identifying genetic markers associated with cancer aggressiveness, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Offit, Kenneth — Sloan-Kettering Inst Can Research
- Study coordinator: Offit, Kenneth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.