Investigating genetic factors in acute lymphoblastic leukemia in African American children
Admixture analysis of acute lymphoblastic leukemia in African American children: the ADMIRAL Study
This study is looking into why kids of African ancestry get B-cell acute lymphoblastic leukemia (B-ALL) less often than kids from other backgrounds, by examining their DNA to find new genetic clues that might explain this difference and how it affects their treatment and recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10930703 on NIH RePORTER |
What this research studies
This research focuses on understanding why children with African ancestry have lower rates of B-cell acute lymphoblastic leukemia (B-ALL) compared to children of other ancestries. By analyzing DNA samples from children with B-ALL, the study aims to identify new genetic factors that may contribute to this difference. The researchers will also explore how these genetic factors relate to clinical characteristics and survival outcomes. This approach combines genetic analysis with clinical data to provide a comprehensive view of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American children diagnosed with B-cell acute lymphoblastic leukemia.
Not a fit: Patients of non-African ancestry or those without a diagnosis of B-ALL may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for acute lymphoblastic leukemia in African American children.
How similar studies have performed: Previous research has shown success in identifying genetic factors related to various cancers, making this approach promising yet still somewhat novel in this specific context.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Spector, Logan G. — University of Minnesota
- Study coordinator: Spector, Logan G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.