Investigating genetic factors and patient differences in Alzheimer's disease
Multiomics data integration methods to discover putative causal variants, genes and patient heterogeneity for Alzheimers disease
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10991325
This study is looking at how our genes and other biological information can help us understand Alzheimer's disease better, so that patients can get more personalized care and possibly new treatments tailored to their specific needs.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10991325 on ClinicalTrials.gov |
What this research studies
This research aims to uncover the genetic variants and molecular processes that contribute to Alzheimer's disease (AD) by integrating various types of biological data. Using advanced computational methods, the project will analyze genetic information, gene expression, and other molecular traits to identify causal factors and understand how AD affects patients differently. By leveraging multiomics data, the research seeks to provide insights into the underlying mechanisms of AD and improve patient stratification based on genetic risk. Patients may benefit from a better understanding of their condition and potential targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with late-onset Alzheimer's disease and those with a family history of the condition.
Not a fit: Patients with early-onset Alzheimer's disease or those without a genetic predisposition to the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment options for Alzheimer's disease patients based on their unique genetic profiles.
How similar studies have performed: Previous research has shown promise in using multiomics approaches to understand complex diseases, suggesting that this methodology could yield valuable insights for Alzheimer's disease as well.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, GAO — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: WANG, GAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease