Investigating genetic factors and microglial function in Alzheimer's disease
Official title: Contribution of AD genetic risk and microglial BIN1 to tauopathy
Funded at University of California, San Diego · NIH-10885645 · Data updated 2026-11-12
This study is looking at how certain genes and brain cells called microglia might affect the risk of developing late-onset Alzheimer's disease, and it invites patients to help by sharing genetic samples to better understand this connection and find new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 30, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $767,112 |
| NIH project number | 1R01AG082255-01A1 |
| Project ID | NIH-10885645 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals with a family history of Alzheimer's disease or those at risk due to genetic factors.
✕Less likely to help
Patients with early-onset Alzheimer's disease or those without any genetic predisposition to AD may not benefit from this research.
What this research studies
This research focuses on understanding how specific genetic variations and the role of microglial cells contribute to the risk of developing late-onset Alzheimer's disease (AD). By utilizing advanced techniques like CRISPR/Cas9, the study aims to explore how these genetic factors influence the behavior of microglia, which are crucial for brain health. The goal is to uncover the molecular mechanisms that lead to AD, potentially paving the way for new therapeutic strategies. Patients may be involved in providing genetic samples or participating in related assessments.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for Alzheimer's disease, improving outcomes for patients.
How similar studies have gone: Previous research has shown promise in understanding genetic contributions to Alzheimer's disease, but this specific approach focusing on BIN1 and microglial function is relatively novel.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Coufal, Nicole Gabriele — University of California, San Diego
- Study coordinator: Coufal, Nicole Gabriele
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.