Investigating genetic factors affecting the stiffness and remodeling of the thoracic aorta
Genetic determinants of thoracic aortic stiffness and remodeling
This study is looking at how our genes might affect the stiffness of a major blood vessel in our chest as we get older, and it’s for people who want to help improve ways to prevent and treat heart-related issues as they age by sharing their health information and genetic samples.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11001486 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic factors contribute to the stiffness and changes in the thoracic aorta as people age. By utilizing large biobanks that contain genomic and imaging data, the study aims to identify specific genetic determinants that influence aortic health. The findings could lead to improved prevention and treatment strategies for age-related aortic conditions. Patients may be involved in providing genetic samples or health data to support this important research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals over 21 years old who are interested in understanding their genetic predisposition to aortic stiffness and related conditions.
Not a fit: Patients with no interest in genetic research or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for conditions related to aortic aging, ultimately improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding genetic factors related to cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Chirinos Medina, Julio Alonso — University of Pennsylvania
- Study coordinator: Chirinos Medina, Julio Alonso
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.