Investigating genetic factors affecting color variation in animals
Official title: Genetic studies of a pleiotropic transmembrane protease: insight from color variation in non-model organisms
Funded at Stanford University · NIH-10899629 · Data updated 2026-11-12
This study is looking at the genes that determine color in animals like cats and zebras, and it aims to find out how these genes work, which could help us understand similar issues in humans, especially those related to skin and color conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | January 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $665,448 |
| NIH project number | 5R01AR082708-03 |
| Project ID | NIH-10899629 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with genetic conditions related to pigmentation or those interested in the genetic basis of color traits.
✕Less likely to help
Patients with unrelated genetic conditions or those not interested in pigmentation genetics may not receive any benefit from this research.
What this research studies
This research explores the genetic basis of pigmentation in various animals, particularly focusing on domestic cats and wild species like zebras. By utilizing advanced genome sequencing technologies, the study aims to identify mutations that influence color traits and their underlying biological pathways. The research combines genetic analysis in non-model organisms with experimental techniques in laboratory mice to uncover insights relevant to human biology and disease. Patients may benefit from understanding how these genetic factors relate to conditions affecting pigmentation and other biological processes.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic factors influencing pigmentation, potentially leading to new insights into human health and disease.
How similar studies have gone: Other research has shown success in using genetic studies of pigmentation in model organisms, suggesting potential for similar breakthroughs in non-model species.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Barsh, Gregory Stefan — Stanford University
- Study coordinator: Barsh, Gregory Stefan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.