Investigating genetic factors affecting cognitive decline and dementia risk in Mexican Americans and non-Hispanic whites
Genetic risk for trajectories of cognitive decline and progression to dementia among Mexican Americans and non-Hispanic whites
This study is looking at how our genes might affect memory and thinking skills as we age, specifically focusing on Mexican Americans and non-Hispanic whites, to help find better ways to support those at risk for dementia.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10525544 on NIH RePORTER |
What this research studies
This research explores how genetic variations influence cognitive decline and the progression to dementia among Mexican Americans and non-Hispanic whites. By utilizing a large cohort from the Texas Alzheimer’s Research and Care Consortium, the study aims to identify ethnicity-specific genetic associations with cognitive functions such as memory and executive function. Participants will be assessed over time to understand how these genetic factors contribute to differences in cognitive health outcomes. The findings could provide insights into tailored interventions for at-risk populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include Mexican Americans and non-Hispanic whites who are experiencing cognitive changes or are at risk for dementia.
Not a fit: Patients who do not belong to the Mexican American or non-Hispanic white ethnic groups may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and targeted prevention strategies for cognitive decline and dementia in diverse populations.
How similar studies have performed: Previous research has shown success in identifying genetic factors related to cognitive decline in other populations, but this study focuses on a relatively under-researched ethnic group, making it a novel approach.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Jian, Xueqiu — University of Texas Hlth Science Center
- Study coordinator: Jian, Xueqiu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.