Investigating genetic factors affecting brain structure in aging and Alzheimer's disease
Genetic Contributors to White Matter Microstructure in Aging and Alzheimers Disease
This study is looking at how our genes might affect the brain's white matter, which is important for memory and thinking, especially as we age or if we have Alzheimer's disease, and it involves patients sharing their genetic and brain scan information to help find ways to better understand and prevent these issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10895375 on NIH RePORTER |
What this research studies
This research aims to uncover the genetic factors that influence the microstructure of white matter in the medial temporal lobe, which is crucial for understanding cognitive decline in aging and Alzheimer's disease. By analyzing data from multiple large-scale aging studies, including the Alzheimer’s Disease Neuroimaging Initiative and others, the researchers will identify specific genes and pathways related to myelination, axonal transport, and neuroinflammation. Patients may be involved in providing genetic and imaging data to help validate these findings, which could lead to better understanding and prevention strategies for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are at risk for Alzheimer's disease or those experiencing cognitive decline.
Not a fit: Patients with early-stage Alzheimer's disease or those with significant cognitive impairment may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic risks of Alzheimer's disease, potentially informing prevention strategies and treatments.
How similar studies have performed: Previous research has shown promising results in identifying genetic factors related to Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Archer, Derek B — Vanderbilt University Medical Center
- Study coordinator: Archer, Derek B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.