Investigating genetic errors that affect the immune system
Official title: Sequencing and sample core: genetic errors of immunity
Funded at Washington University · NIH-11010135 · Data updated 2026-11-12
This study is looking at how certain genetic mistakes can cause problems with the immune system, leading to issues like infections and allergies, and it's for people who have these immune-related conditions or come from families where not everyone is affected.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 8, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $413,985 |
| NIH project number | 1P01AI186771-01 |
| Project ID | NIH-11010135 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with immune dysregulation syndromes, such as autoimmune diseases, allergies, or unexplained immune issues.
✕Less likely to help
Patients with well-defined genetic causes of their immune disorders that have already been identified may not benefit from this research.
What this research studies
This research focuses on understanding genetic errors that lead to various immune dysregulation syndromes, which can cause issues like infections, allergies, and autoimmune diseases. By utilizing advanced next-generation sequencing techniques, the project aims to identify and characterize over 500 genetic lesions associated with these conditions. The research will analyze samples from individuals with unknown or known genetic lesions, particularly those from families where the disease does not consistently affect all members. This approach will help uncover the complexities of genetic influences on immune health and disease.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment options for patients with immune-related disorders.
How similar studies have gone: Previous research utilizing next-generation sequencing has shown promise in identifying genetic causes of immune disorders, indicating that this approach is both relevant and potentially impactful.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Bogunovic, Dusan — Washington University
- Study coordinator: Bogunovic, Dusan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.