Investigating genetic elements that may influence human traits and diseases
In vivo characterization of CNE/SNPs and identification of cis (dys)regulated genes
This study is looking at special parts of our DNA that stay the same across different species, like humans and zebrafish, to see how they might be connected to traits and health issues, such as heart health and eye conditions, so we can learn more about how our genes work and what that means for our health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10744189 on NIH RePORTER |
What this research studies
This research focuses on Conserved Non-protein coding Elements (CNEs), which are DNA sequences that are highly preserved across different species, including humans. The team aims to identify specific CNEs associated with genetic variations linked to various human traits and diseases, such as cardiovascular health and eye biology. By using zebrafish as a model organism, they will explore how these genetic elements function and how certain genetic variations can affect their activity. This approach allows for a better understanding of the underlying biology of these traits and the potential implications for human health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic predispositions to cardiovascular issues, eye disorders, or other traits being studied.
Not a fit: Patients with conditions unrelated to the traits being investigated, or those without genetic variations linked to the studied CNEs, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into genetic factors influencing common human traits and diseases, potentially guiding future treatments.
How similar studies have performed: Previous research has shown promise in using similar genetic approaches to uncover the roles of non-coding elements in human biology, indicating that this methodology has potential for success.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Mourrain, Philippe — Stanford University
- Study coordinator: Mourrain, Philippe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.