Investigating genetic differences affecting the risk of orofacial clefts based on sex
Differences between the sexes among genetic variants affecting orofacial cleft birth defect risk
This study is looking at how our genes might affect the chances of having orofacial clefts, like cleft lip and palate, and it wants to see if there are differences between boys and girls; the goal is to find out more about the genetic factors involved so that we can improve prevention and treatment options for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10765745 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic variants influence the risk of orofacial clefts, such as cleft lip and palate, with a particular emphasis on differences between sexes. By analyzing genetic data from diverse populations, the study aims to identify specific genes and alleles that contribute to these birth defects. The methodology includes genome-wide association studies to uncover the genetic factors involved, which could lead to better prevention and treatment strategies for affected individuals. Patients may benefit from insights into the genetic risks associated with orofacial clefts, potentially guiding future healthcare decisions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of orofacial clefts or those who have been diagnosed with these conditions.
Not a fit: Patients without any genetic predisposition to orofacial clefts or those not affected by these conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for orofacial clefts, benefiting families at risk.
How similar studies have performed: Previous research has shown success in identifying genetic factors associated with orofacial clefts, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Ruczinski, Ingo — Johns Hopkins University
- Study coordinator: Ruczinski, Ingo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.