Investigating genetic changes that lead to cancer in diverse populations
Admixture mapping of mosaic copy number alterations for identification of cancer drivers
This study is looking at how certain genetic changes in our blood can affect the risk of developing blood cancers, and it's for anyone interested in understanding how these changes might differ among people from different backgrounds to help with early detection and prevention.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10828309 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic changes, specifically somatic mosaicism, contribute to the development of cancer. By studying blood samples from individuals of various ancestries, the research aims to identify specific genetic alterations that increase the risk of hematological malignancies. The approach involves analyzing copy number alterations in the DNA of these individuals to uncover differences in cancer risk among diverse populations. This could lead to improved strategies for early detection and prevention of cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from minority populations, particularly those of African American or Latino ancestry, who may be at higher risk for certain cancers.
Not a fit: Patients who do not belong to the targeted minority populations or those without a family history of hematological malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and prevention strategies for cancer in underrepresented populations.
How similar studies have performed: Previous research has shown that understanding genetic variations in diverse populations can lead to significant advancements in cancer prevention and treatment, indicating the potential success of this approach.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Jakubek Swartzlander, Yasminka Aleksandra — University of Kentucky
- Study coordinator: Jakubek Swartzlander, Yasminka Aleksandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.