Investigating genetic changes in pediatric acute myeloid leukemia
UBTF Tandem Duplications in Pediatric Acute Myeloid Leukemia
This study is looking at the genetic changes in kids with acute myeloid leukemia (AML) who have had a relapse, to better understand why some treatments don’t work and how these changes affect the disease, so we can find better ways to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10933513 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic alterations in children diagnosed with acute myeloid leukemia (AML), particularly those who experience relapse. The team has identified specific genetic changes, including tandem duplications of the UBTF gene, that are associated with poor outcomes in these patients. By analyzing samples from children with relapsed AML, the researchers aim to uncover the mechanisms driving this disease and its resistance to standard treatments. The study employs advanced techniques such as ATAC sequencing to explore how these genetic changes affect cell behavior and leukemia development.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with acute myeloid leukemia, particularly those who have experienced relapse.
Not a fit: Patients with other types of leukemia or those who are adults may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and better outcomes for children with acute myeloid leukemia.
How similar studies have performed: Other research has shown promising results in identifying genetic alterations in leukemia, suggesting that this approach could yield valuable insights.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Klco, Jeffery M — St. Jude Children's Research Hospital
- Study coordinator: Klco, Jeffery M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.