Investigating genetic changes in pediatric acute myeloid leukemia
Official title: UBTF Tandem Duplications in Pediatric Acute Myeloid Leukemia
Funded at St. Jude Children's Research Hospital · NIH-10933513 · Data updated 2026-11-12
This study is looking at the genetic changes in kids with acute myeloid leukemia (AML) who have had a relapse, to better understand why some treatments don’t work and how these changes affect the disease, so we can find better ways to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $395,510 |
| NIH project number | 5R01CA276079-02 |
| Project ID | NIH-10933513 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with acute myeloid leukemia, particularly those who have experienced relapse.
✕Less likely to help
Patients with other types of leukemia or those who are adults may not receive benefit from this research.
What this research studies
This research focuses on understanding the genetic alterations in children diagnosed with acute myeloid leukemia (AML), particularly those who experience relapse. The team has identified specific genetic changes, including tandem duplications of the UBTF gene, that are associated with poor outcomes in these patients. By analyzing samples from children with relapsed AML, the researchers aim to uncover the mechanisms driving this disease and its resistance to standard treatments. The study employs advanced techniques such as ATAC sequencing to explore how these genetic changes affect cell behavior and leukemia development.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and better outcomes for children with acute myeloid leukemia.
How similar studies have gone: Other research has shown promising results in identifying genetic alterations in leukemia, suggesting that this approach could yield valuable insights.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Klco, Jeffery M — St. Jude Children's Research Hospital
- Study coordinator: Klco, Jeffery M
Related research
Other NIH-funded projects on the same topics.
-
Targeting the SCP4 pathway in acute myeloid leukemia (AML)
Aims to uncover how the SCP4 signaling pathway drives AML and how it could be blocked to help patients.
-
Interferon-γ plus donor immune cells to fight AML/MDS after partial donor transplant
This project tests a therapy that adds a signaling protein, IFN-γ, with donor immune cells to help treat relapsed AML/MDS after a haploidentical stem cell transplant.
-
Targeting the protein housekeeping system in adult leukemia
Researchers are testing a new approach to treat acute myeloid leukemia by disrupting how AML cells manage their proteins, with the goal of helping patients live longer and healthier lives.
-
Understanding how epigenetic helper proteins drive AML and how to target them
A scientist team is studying how accessory proteins in gene-regulating complexes affect acute myeloid leukemia and whether they can be targeted for safer, more precise therapies.
-
Targeting FLVCR1-enabled choline use in a aggressive AML subtype
A new approach aims to block how a specific leukemia subtype (CG-AML) takes up choline to feed its growth, potentially slowing or stopping the disease.
-
Advancing CD70-targeted CAR-NK Therapy for AML
A patient-focused look at a new cell therapy that uses engineered NK cells to target AML by hitting CD70, aiming to reduce relapse with potentially fewer blood cell problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.