Investigating genetic changes in autism spectrum disorder
Somatic mutations in autism spectrum disorder
['FUNDING_CAREER'] · BOSTON CHILDREN'S HOSPITAL · NIH-10865573
This study is looking at how certain genetic changes that happen after birth might play a role in autism spectrum disorder (ASD) in children, with the hope of finding better ways to diagnose and treat the condition.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10865573 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the genetic factors that contribute to autism spectrum disorder (ASD) by analyzing somatic mutations in children. The project will utilize advanced sequencing techniques to identify genetic variations that occur after conception and may influence the development of ASD. Dr. Alisa Mo, under the mentorship of Dr. Christopher A. Walsh, will develop expertise in human genetics and computational genomics to interpret these mutations. The research aims to uncover the biological mechanisms behind ASD, which could lead to improved diagnostic and therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with autism spectrum disorder.
Not a fit: Patients who do not have autism spectrum disorder or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of autism and lead to better diagnostic tools and treatments for affected children.
How similar studies have performed: Previous research has shown promising results in understanding genetic contributions to autism, making this approach both relevant and potentially impactful.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MO, ALISA — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: MO, ALISA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder