Investigating genetic changes and targeted treatments for Adult T-cell leukemia in North America
Epigenetic Alterations and Targeted Therapies in North American ATLL
This study is looking at how the genes of people with Adult T-cell leukemia/lymphoma (ATLL) in North America differ from those in Japan, to find new ways to treat this serious cancer caused by a virus, and it’s designed for patients who want to learn more about potential new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11062477 on NIH RePORTER |
What this research studies
This research focuses on Adult T-cell leukemia/lymphoma (ATLL), a serious condition affecting patients with human T-lymphotropic virus-1 (HTLV-1). The study aims to understand the genetic alterations that occur in North American patients compared to those in Japan, particularly looking at mutations that affect epigenetic modifications. By analyzing patient samples, the researchers hope to identify new therapeutic strategies that could improve treatment outcomes for this aggressive cancer. The approach includes targeted sequencing and assessing the sensitivity of cancer cells to specific inhibitors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Adult T-cell leukemia/lymphoma, particularly those who are HTLV-1 carriers.
Not a fit: Patients with other types of leukemia or those not infected with HTLV-1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective targeted therapies for Adult T-cell leukemia, significantly improving survival rates.
How similar studies have performed: While there has been significant research on ATLL in Japan, this specific focus on North American patients and their unique genetic profile is relatively novel.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Ye, Bihui Hilda — Albert Einstein College of Medicine
- Study coordinator: Ye, Bihui Hilda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.